Article

In vivo Proximity & Spatial Proteomics with CRISPR Screening Identify STXBP1 as a Protective Modifier of α-synuclein Toxicity in Dopamine Neurons

2026-01-17

Abstract excerpt

<h4>Summary</h4> Parkinson’s disease (PD) is a disease of adults involving the loss of dopaminergic neurons after a long, asymptomatic, prodromal period. α-synuclein, LRRK2, and VPS35 are linked to familial PD, however, how these mutations predispose dopamine neurons to death during the early prodromal phases remains unclear. Here, we used in vivo native proximity proteomics (iBioID) and dopaminergic neuron-speci...

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Literature Corpus work: ade0cd53-0a81-5661-ac05-73cd37ec10dc
DOI: 10.64898/2026.01.16.699530

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