Article

<i>Mycobacterium tuberculosis</i> senses host Interferon-γ via the membrane protein MmpL10

2021-11-12

Abstract excerpt

Mycobacterium tuberculosis (Mtb) is one of the most successful human pathogens and remains a leading cause of death from infectious disease. Interferon-γ (IFN-γ) is a central regulator of the immune defense against Mtb . Several cytokines have been shown to increase virulence of other bacterial pathogens, leading us to investigate whether IFN-γ has a direct effect on Mtb . We found that both recombinant and T-ce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bc5a7fc5-ec7d-596f-bb69-d9a493858b1a
DOI: 10.1101/2021.11.12.468344

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Mycobacterium tuberculosis</i> senses host Interferon-γ via the membrane protein MmpL10DOI 10.1101/2021.11.12.468344Read

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10Semantic proximity Read

Species-specific iNOS expression distinguishes epithelial and myeloid IFNγ responses in tuberculosisSemantic proximity Read

Shared and distinct responses of human and murine alveolar macrophages and monocyte-derived macrophages to <i>Mycobacterium tuberculosis</i>Semantic proximity Read

c-Myc inhibits macrophage antimycobacterial response in <i>Mycobacterium tuberculosis</i> infectionSemantic proximity Read

Exposure to <i>mycobacterium</i> remodels alveolar macrophages and the early innate response to <i>Mycobacterium tuberculosis</i> infectionSemantic proximity Read

<i>Mycobacterium tuberculosis</i> Triggers Host Type I IFN Signaling To Regulate IL-1β Production in Human MacrophagesSemantic proximity Read

Tissue specific diversification, virulence and immune response to Mycobacterium bovis BCG in a patient with an IFN-γ R1 deficiency.Semantic proximity Read

Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responsesSemantic proximity Read

Exposure of <i>Mycobacterium tuberculosis</i> to human alveolar lining fluid shows temporal and strain-specific adaptation to the lung environmentSemantic proximity Read

Type I Interferons in the Pathogenesis of Tuberculosis: Molecular Drivers and Immunological ConsequencesSemantic proximity Read

Comparative ‘omics analyses differentiate <i>Mycobacterium tuberculosis</i> and <i>Mycobacterium bovis</i> and reveal distinct macrophage responses to infection with the human and bovine tubercle bacilliSemantic proximity Read

Combining Interferon-γ Release Assays and Metagenomic Next-generation Sequencing for Diagnosis of Pulmonary Tuberculosis: A Retrospective StudySemantic proximity Read