Article

Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses

2020-12-17

Abstract excerpt

<h4>SUMMARY</h4> Tuberculosis (TB) remains a major public health problem with host-directed therapeutics offering potential as novel treatment strategies. However, their successful development still requires a comprehensive understanding of how Mycobacterium tuberculosis ( M.tb ) infection impacts immune responses. To address this challenge, we applied standardised immunomonitoring tools to compare TB antigen,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fc9f42e7-4882-5d06-a7c4-add5b7f92ba7
DOI: 10.1101/2020.12.17.423082

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responsesDOI 10.1101/2020.12.17.423082Read

Beyond the Clinic: The Activation of Diverse Cellular and Humoral Factors Shapes the Immunological Status of Patients with Active TuberculosisSemantic proximity Read

Advances in understanding immune homeostasis in latent tuberculosis infectionSemantic proximity Read

Inflammation in tuberculosis: interactions, imbalances and interventionsSemantic proximity Read

The Troika Host–Pathogen–Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical OutcomesSemantic proximity Read

Immune endotypes in tuberculosis: Keys to decoding disease complexity.Semantic proximity Read

Viewpoint of multi-omics potential in tuberculosis research: identifying biomarkers for biomanufacturing of efficient control toolsSemantic proximity Read

Inflammation and tuberculosis: host‐directed therapiesSemantic proximity Read

Genome-Wide Expression Profiling Identifies Type 1 Interferon Response Pathways in Active TuberculosisSemantic proximity Read

From simple to complex: Protein‐based biomarker discovery in tuberculosisSemantic proximity Read

Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease OutcomeSemantic proximity Read

Integrative and comparative genomic analyses of mammalian macrophage responses to intracellular mycobacterial pathogensSemantic proximity Read

Exploring T-cell metabolism in tuberculosis: development of a diagnostic model using metabolic genesSemantic proximity Read