Article

c-Myc inhibits macrophage antimycobacterial response in <i>Mycobacterium tuberculosis</i> infection

2025-01-13

Abstract excerpt

Mycobacterium tuberculosis (MTB) is a major global cause of mortality worldwide, responsible for over a million deaths annually. Despite this burden, natural immunity prevents disease in more than 90% of exposed individuals. Previous studies have identified interferon-gamma (IFN-γ) as a key regulator of innate immune defense against MTB. Here, we investigate the impact of IFN-γ timing on macrophage-mediated contro...

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Literature Corpus work: a76264e3-f70b-5674-8000-3848d1e4820c
DOI: 10.1101/2025.01.09.632095

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