Article

Species-specific iNOS expression distinguishes epithelial and myeloid IFNγ responses in tuberculosis

2026-01-12

Abstract excerpt

<h4>Rationale</h4> Tuberculosis vaccines aim to elicit protective immunity, with IFNγ-producing CD4⁺ T cells considered central mediators of host defense. In murine models, IFNγ activates macrophages to induce inducible nitric oxide synthase (iNOS), resulting in nitric oxide–dependent control of Mycobacterium tuberculosis ( Mtb ). <h4>Objective</h4> To define the relevance of IFNγ-induced iNOS activity in hum...

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Literature Corpus work: 4c21fd55-0124-57c0-a071-d720d2978409
DOI: 10.64898/2026.01.11.697682

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