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Comparative ‘omics analyses differentiate <i>Mycobacterium tuberculosis</i> and <i>Mycobacterium bovis</i> and reveal distinct macrophage responses to infection with the human and bovine tubercle bacilli

2017-11-16

Abstract excerpt

Members of the Mycobacterium tuberculosis complex (MTBC) are the causative agents of tuberculosis in a range of mammals, including humans. A key feature of MTBC pathogens is their high degree of genetic identity, yet distinct host tropism. Notably, while Mycobacterium bovis is highly virulent and pathogenic for cattle, the human pathogen M. tuberculosis is attenuated in cattle. Previous research also suggests t...

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Literature Corpus work
359503a9-53b5-510d-a325-db4f430cb9c5
DOI
10.1101/220624
Open publication

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Comparative ‘omics analyses differentiate <i>Mycobacterium tuberculosis</i> and <i>Mycobacterium bovis</i> and reveal distinct macrophage responses to infection with the human and bovine tubercle bacilliDOI 10.1101/220624
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