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Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10

1 Dec 2022

Abstract excerpt

Mycobacterium tuberculosis (Mtb) is one of the most successful human pathogens. Several cytokines are known to increase virulence of bacterial pathogens, leading us to investigate whether Interferon-γ (IFN-γ), a central regulator of the immune defense against Mtb, has a direct effect on the bacteria. We found that recombinant and T-cell derived IFN-γ rapidly induced a dose-dependent increase in the oxygen...

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PMID: 36456824
DOI: 10.1038/s42003-022-04265-0

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