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<i>Mycobacterium tuberculosis</i> Triggers Host Type I IFN Signaling To Regulate IL-1β Production in Human Macrophages

23 Jul 2011

Abstract excerpt

Mycobacterium tuberculosis is a virulent intracellular pathogen that survives in macrophages even in the presence of an intact adaptive immune response. Type I IFNs have been shown to exacerbate tuberculosis in mice and to be associated with disease progression in infected humans. Nevertheless, the mechanisms by which type I IFNs regulate the host response to M. tuberculosis infection are poorly understood. In...

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PMID: 21784976
DOI: 10.4049/jimmunol.1100926

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