Article
Tissue specific diversification, virulence and immune response to Mycobacterium bovis BCG in a patient with an IFN-γ R1 deficiency.
Virulence - 1 Dec 2020
Korol Cecilia B, Shallom Shamira J, Arora Kriti, Boshoff Helena I, Freeman Alexandra F, King Alejandra, Agrawal Sonia, Daugherty Sean C, Jancel Timothy, Kabat Juraj, Ganesan Sundar, Torrero Marina N, Sampaio Elizabeth P, Barry Clifton, Holland Steve M, Tettelin Hervé, Rosenzweig Sergio D, Zelazny Adrian M
Abstract excerpt
Summary: We characterized Mycobacterium bovis BCG isolates found in lung and brain samples from a previously vaccinated patient with IFNγR1 deficiency. The isolates collected displayed distinct genomic and phenotypic features consistent with host adaptation and associated changes in antibiotic susceptibility and virulence traits. Background: We report a case of a patient with partial recessive IFNγR1 deficiency...
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