Article

Microglial amyloid beta clearance is driven by PIEZO1 channels

2022-03-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Microglia are the endogenous immune cells of the brain and act as sensors of pathology to maintain brain homeostasis and eliminate potential threats. In Alzheimer’s disease (AD), toxic amyloid beta (Aβ) accumulates in the brain and forms stiff plaques. In late-onset AD accounting for 95% of all cases, this is thought to be due to reduced clearance of Aβ. Human genome-wide as...

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Literature Corpus work: bc4dd23a-87f9-5545-b7a9-420b24785180
DOI: 10.1101/2022.03.18.484831

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