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Article

Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice

1 Jun 2022

Abstract excerpt

Microglia are strongly implicated in the development and progression of Alzheimer's disease (AD), yet their impact on pathology and lifespan remains unclear. Here we utilize a CSF1R hypomorphic mouse to generate a model of AD that genetically lacks microglia. The resulting microglial-deficient mice exhibit a profound shift from parenchymal amyloid plaques to cerebral amyloid angiopathy (CAA), which is accompanied...

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PMID: 35705056
DOI: 10.1016/j.celrep.2022.110961

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