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Article

Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia.

Frontiers in immunology - 1 Jan 2020

Reich Marvin, Paris Iñaki, Ebeling Martin, Dahm Nadine, Schweitzer Christophe, Reinhardt Dieter, Schmucki Roland, Prasad Megana, Köchl Fabian, Leist Marcel, Cowley Sally A, Zhang Jitao David, Patsch Christoph, Gutbier Simon, Britschgi Markus

Abstract excerpt

Microglia are key in the homeostatic well-being of the brain and microglial dysfunction has been implicated in neurodegenerative disorders such as Alzheimer's disease (AD). Due to the many limitations to study microglia in situ or isolated for large scale drug discovery applications, there is a high need to develop robust and scalable human cellular models of microglia with reliable translatability to the...

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Identifiers

PMID: 33613545
DOI: 10.3389/fimmu.2020.617860
PMCID: PMC7887311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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