Article

PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis

2024-07-18

Abstract excerpt

<title>Abstract</title> <p>The rising incidences of atherosclerosis have necessitated efforts to identify novel targets for therapeutic interventions. In the present study, we observed increased expression of the mechanosensitive calcium channel Piezo1 transcript in mouse and human atherosclerotic plaques, correlating with infiltration of PIEZO1-expressing macrophages. <italic>In vitro</italic> administration of...

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Literature Corpus work: 33dc10fe-f28e-5965-b41f-6d45cee8d43d
DOI: 10.21203/rs.3.rs-4539639/v1

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