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Article

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

21 May 2021

Abstract excerpt

Abstract The role of microglia cells in Alzheimer’s disease (AD) is well recognized, however their molecular and functional diversity remain unclear. Here, we isolated amyloid plaque-containing (using labelling with methoxy-XO4, XO4 + ) and non-containing (XO4 − ) microglia from an AD mouse model. Transcriptomics analysis identified different transcriptional trajectories in ageing and AD mice. XO4 + microglial...

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PMID: 34021136
DOI: 10.1038/s41467-021-23111-1

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