Article

Targeting PIEZO1 refines macrophage function in atherosclerosis

2022-10-06

Abstract excerpt

<title>Abstract</title> <p>The increasing prevalence of global atherosclerosis and its complications demand efforts to discover novel targets for therapeutic interventions. In the present study, we identified increased expression of the mechanosensitive calcium channel Piezo 1 transcripts in mouse and human atherosclerosis, driven by infiltration of PIEZO1-expressing macrophages. We pharmacologically activated or...

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Identifiers and source

Literature Corpus work: 34eeae51-e234-59d4-8a5c-51cb4bdf98dd
DOI: 10.21203/rs.3.rs-2057017/v1

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