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Isotope Dilution nanoLC-MS/MS Quantitation of Methylglyoxal DNA-Protein Crosslinks: Formation and Repair in Human Cells

2025-10-30

Abstract excerpt

<h4>ABSTRACT</h4> DNA-protein crosslinks (DPCs) represent a prevalent form of DNA damage that form when cellular proteins become covalently trapped to DNA strands upon exposure to various endogenous and exogenous agents. Methylglyoxal, is an endogenous metabolite that reacts with guanine and adenine bases in DNA and RNA, as well as cysteine, arginine and lysine residues in proteins, generating advanced glycation...

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Literature Corpus work
bc42da11-3c3c-52c2-994b-499782f85b64
DOI
10.1101/2025.10.28.685209
Open publication

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Isotope Dilution nanoLC-MS/MS Quantitation of Methylglyoxal DNA-Protein Crosslinks: Formation and Repair in Human CellsDOI 10.1101/2025.10.28.685209
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