Article

NLRP10 Cleaves Oxidized DNA inhibited by OGG1 inhibitors: A Newly Identified Role in DNA Damage Processing and Senescence Regulation

2025-03-12

Abstract excerpt

<h4>SUMMARY</h4> Mitochondrial DNA (mtDNA) release into the cytosol is a critical event in innate immune activation, often acting as a damage-associated molecular pattern (DAMP) that triggers inflammasome assembly. Here, we demonstrate that NLRP3 plays a direct role in cleaving and facilitating the release of D-loop mtDNA into the cytosol. We further show that NLRP3 interacts with NLRP10. NLRP10-mediated ox-DNA c...

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Literature Corpus work: 7d63fe63-2c12-5d25-a926-e5c21f8c4e87
DOI: 10.1101/2025.03.07.642110

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