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Proteomics insights into DNA damage response and translating this knowledge to clinical strategies

28 Sept 2016

Abstract excerpt

Genomic instability is a critical driver in the process of cancer formation. At the same time, inducing DNA damage by irradiation or genotoxic compounds constitutes a key therapeutic strategy to kill fast-dividing cancer cells. Sensing of DNA lesions initiates a complex set of signalling pathways, collectively known as the DNA damage response (DDR). Deciphering DDR signalling pathways with high-throughput...

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PMID: 27682984
DOI: 10.1002/pmic.201600018

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