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Article

Formation and genotoxicity of a guanine-cytosine intrastrand cross-link lesion in vivo.

Nucleic acids research - 1 Jan 2007

Hong Haizheng, Cao Huachuan, Wang Yinsheng

Abstract excerpt

Reactive oxygen species (ROS) can be induced by both endogenous and exogenous processes, and they can damage biological molecules including nucleic acids. Exposure of isolated DNA to X/gamma-rays and Fenton reagents was shown to lead to the formation of intrastrand cross-link lesions where the neighboring nucleobases in the same DNA strand are covalently bonded. By employing HPLC coupled with tandem mass...

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Identifiers

PMID: 17942427
DOI: 10.1093/nar/gkm851
PMCID: PMC2175358

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