Article

A Cyclic Arginine Adduct Eclipses Carboxymethylation as the Primary Glyoxal-Derived Advanced Glycation End-Product

2025-05-30

Abstract excerpt

Glyoxal (GO) is a highly reactive 1,2 dialdehyde implicated in the formation of a set of disease-associated post-translational modifications (PTMs) known as advanced glycation end products (AGEs). While GO has been widely reported to modify lysine to form the highly studied AGE carboxymethyllysine (CML), here we demonstrate that GO alone leads to highly chemoselective arginine glycation, yielding a stable glyoxal-...

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Identifiers and source

Literature Corpus work: 41ef71ee-d276-592f-8bd3-56640c3dab16
DOI: 10.1101/2025.05.27.656459

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A Cyclic Arginine Adduct Eclipses Carboxymethylation as the Primary Glyoxal-Derived Advanced Glycation End-ProductDOI 10.1101/2025.05.27.656459Read

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