Back to search

Article

Targeted quantification assays for DNA repair and handling proteins and interactions in Huntington’s disease models

2026-07-29

Abstract excerpt

Huntington’s disease (HD) is a life-altering genetic neurodegenerative disorder, with cognitive, motor, and psycho-social effects that have consequential impacts on the individuals and their families. While current treatments improve disease symptoms, there are no FDA-approved therapies that prevent disease progression. Converging lines of evidence from human GWAS and mouse models point to DNA repair and handling...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
69b36962-2bf4-5c40-b86e-c012a2db70a8
DOI
10.64898/2026.07.28.741339
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Targeted quantification assays for DNA repair and handling proteins and interactions in Huntington’s disease modelsDOI 10.64898/2026.07.28.741339
Mismatch repair dissection by in vivo RNAi reveals dose-dependent modulators of somatic instability and proteome remodeling in Huntington’s diseaseSemantic proximity
Genetic modifiers of somatic expansion and clinical phenotypes in Huntington's disease highlight shared and tissue-specific effects.Semantic proximity
Unscheduled DNA synthesis reveals a DNA repair hotspot and biomarker of somatic instability at the expanded-CAG repeat tract in the huntingtin geneSemantic proximity
Msh3 and Pms1 Set Neuronal CAG-repeat Migration Rate to Drive Selective Striatal and Cortical Pathogenesis in HD MiceSemantic proximity
Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD miceSemantic proximity
Therapeutic validation of MMR-associated genetic modifiers in a human <i>ex vivo</i> model of Huntington’s diseaseSemantic proximity
The “adductome”: a limited repertoire of adducted proteins in human cellsSemantic proximity
RNA/DNA Binding Protein TDP43 Regulates DNA Mismatch Repair Genes with Implications for Genome StabilitySemantic proximity
Huntington’s disease LIG1 modifier variant increases ligase fidelity and suppresses somatic CAG repeat expansionSemantic proximity
Challenges and advances for huntingtin detection in cerebrospinal fluid: in support of relative quantificationSemantic proximity
Isotope Dilution nanoLC-MS/MS Quantitation of Methylglyoxal DNA-Protein Crosslinks: Formation and Repair in Human CellsSemantic proximity
PAQMAN: Protein-nucleic acid affinity quantification by MAss spectrometry in nuclear extracts.Semantic proximity
Select a neighboring publication to make it the new centre.