Article

The oncometabolite L-2-hydroxyglutarate is a common product of Dipteran larval development

2020-05-06

Abstract excerpt

<h4>ABSTRACT</h4> The oncometabolite L-2-hydroxyglutarate (L-2HG) is considered an abnormal product of central carbon metabolism that is capable of disrupting chromatin architecture, mitochondrial metabolism, and cellular differentiation. Under most circumstances, mammalian tissues readily dispose of this compound, as aberrant L-2HG accumulation induces neurometabolic disorders and promotes renal cell carcinomas....

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Literature Corpus work: f2fcc258-1395-51c7-91a8-d00473a2845c
DOI: 10.1101/2020.05.05.078857

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