Article
Non-enzymatic RNA Glycation is a Metabolic Sensor of Cellular Stress
2026-05-19
Abstract excerpt
<h4>Summary</h4> Non-enzymatic RNA modifications expand the epitranscriptome, encoding a rapid and chemistry-driven response to cellular stress. While methylglyoxal, a reactive glycolytic byproduct of metabolic stress, has been shown to modify proteins and DNA, its impact on RNA has remained unexplored. Here, we identify mRNA as a dynamic substrate of MGO, whose modification is actively regulated by DJ-1 and the...
Topics
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Identifiers and source
- Literature Corpus work
- 06a9b041-7358-50cd-8f0f-68afff3929b8
- DOI
- 10.64898/2026.05.18.725511