Article

Flap endonuclease 1 repairs DNA-protein crosslinks via ADP-ribosylation

2023-10-19

Abstract excerpt

DNA-protein crosslinks (DPCs) are among the most ubiquitous and detrimental DNA lesions which arise from exposure to metabolic stresses, drugs, or crosslinking agents such as formaldehyde (FA). FA is a cellular by-product of methanol metabolism, histone demethylation, lipid peroxidation as well as environmental pollutants. Failure to repair FA-induced DPCs blocks nearly all chromatin-based processes including repl...

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Literature Corpus work: 561ff9b8-5215-530a-8b83-8287a099c890
DOI: 10.1101/2023.10.19.563118

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