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Protein Arginine Deiminase 4 Antagonizes Methylglyoxal-induced Histone Glycation

2019-10-31

Abstract excerpt

Protein arginine deiminase 4 (PAD4) facilitates the post-translational citrullination of the core histones H3 and H4. While the precise epigenetic function of this modification has not been resolved, it was shown to associate with general chromatin decompaction and to compete with arginine methylation. Recently, we showed that histones are subjected to methylglyoxal (MGO)-induced glycation on nucleophilic side cha...

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Literature Corpus work
8ffae4f3-26e6-5501-b1c5-008972171235
DOI
10.1101/826818
Open publication

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Protein Arginine Deiminase 4 Antagonizes Methylglyoxal-induced Histone GlycationDOI 10.1101/826818
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