Article

Tracing the evolution of single-cell cancer 3D genomes: an atlas for cancer gene discovery

2023-07-24

Abstract excerpt

Although three-dimensional (3D) genome structures are altered in cancer cells, little is known about how these changes evolve and diversify during cancer progression. Leveraging genome-wide chromatin tracing to visualize 3D genome folding directly in tissues, we generated 3D genome cancer atlases of murine lung and pancreatic adenocarcinoma. Our data reveal stereotypical, non-monotonic, and stage-specific alterati...

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Literature Corpus work: bc1cbb63-859d-530d-afd8-b7d37ecd397c
DOI: 10.1101/2023.07.23.550157

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