Article

Integrative spatial profiling of 3D genome organization and gene expression in tissue

2026-07-31

Abstract excerpt

The interplay between 3D genome architecture and transcriptional activity is fundamental to gene regulation. However, existing methodologies cannot simultaneously measure these modalities within intact tissues, limiting our understanding of how genome organization coordinates transcriptional programs across diverse cell types and spatial microenvironments. Here, we introduce Spatial Hi-C-RNA, a spatial multi-omics...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e5fc1b32-44d7-58e5-9b10-b733f5a03fce
DOI: 10.64898/2026.07.28.741242

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative spatial profiling of 3D genome organization and gene expression in tissueDOI 10.64898/2026.07.28.741242Read

Tracing the evolution of single-cell cancer 3D genomes: an atlas for cancer gene discoverySemantic proximity Read

Droplet Hi-C for Fast and Scalable Profiling of Chromatin Architecture in Single CellsSemantic proximity Read

Spatial-ATAC-seq: spatially resolved chromatin accessibility profiling of tissues at genome scale and cellular levelSemantic proximity Read

Spatial joint profiling of DNA methylome and transcriptome in mammalian tissuesSemantic proximity Read

Tracing the evolution of single-cell 3D genomes in Kras-driven cancersSemantic proximity Read

Spatial-ATAC-seq: spatially resolved chromatin accessibility profiling of tissues at genome scale and cellular levelSemantic proximity Read

Spatial profiling of chromatin accessibility in mouse and human tissuesSemantic proximity Read

Spatially resolved whole transcriptome profiling in human and mouse tissue using Digital Spatial ProfilingSemantic proximity Read

Spatial Epigenome Sequencing at Tissue Scale and Cellular LevelSemantic proximity Read

Chromatin accessibility profiling in tissue sections by spatial ATACSemantic proximity Read

Hi-Compass resolves cell-type chromatin interactions by single-cell and spatial ATAC-seq data across biological scalesSemantic proximity Read

Spatially resolved epigenome-transcriptome co-profiling of mammalian tissues at the cellular levelSemantic proximity Read