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Article

Rewiring cancer: 3D genome determinants of cancer hallmarks.

Current opinion in genetics & development - 1 Apr 2025

Amodeo Maria E, Eyler Christine E, Johnstone Sarah E

Abstract excerpt

In modern cancer biology, Hanahan and Weinberg's classic depiction of the Hallmarks of Cancer serves as a heuristic for understanding malignant phenotypes [1]. Genetic determinants of these phenotypes promote cancer induction and progression, and these mutations drive current approaches to understanding and treating cancer. Meanwhile, for over a century, pathologists have noted that profound alterations of...

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PMID: 39862605
DOI: 10.1016/j.gde.2024.102307
PMCID: PMC11867856

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