Article

PHF19 drives PRC2 sub-nuclear compartmentalization to promote motility in TNBC cells

2025-03-14

Abstract excerpt

Polycomb Repressive Complex 2 (PRC2) is a key regulator of chromatin architecture and transcriptional repression, playing essential roles in development and disease. While its enzymatic activity is well characterized, the molecular factors governing PRC2 subnuclear organization, particularly in cancer cells, are largely unknown. Here, we integrate high-resolution in situ spatial proteomics, imaging, and functiona...

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Identifiers and source

Literature Corpus work: 9a310305-7a52-5ded-a644-ef52a65c428f
DOI: 10.1101/2025.03.13.642950

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