Article

Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis

2019-06-17

Abstract excerpt

<h4>SUMMARY</h4> Aberrant chromatin structure is a hallmark in cancer cells and has long been used for clinical diagnosis of cancer. However, underlying higher-order chromatin folding during malignant transformation remains elusive, due to the lack of molecular scale resolution. Using optimized stochastic optical reconstruction microscopy (STORM) for pathological tissue (PathSTORM), we uncovered a gradual decompa...

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Literature Corpus work: 5f44f4fd-3f57-54bd-afca-619fa93cecf4
DOI: 10.1101/672105

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