Article

Human Body Single-Cell Atlas of 3D Genome Organization and DNA Methylation

2025-03-24

Abstract excerpt

Higher-order chromatin structure and DNA methylation are critical for gene regulation, but how these vary across the human body remains unclear. We performed multi-omic profiling of 3D genome structure and DNA methylation for 86,689 single nuclei across 16 human tissues, identifying 35 major and 206 cell subtypes. We revealed extensive changes in CG and non-CG methylation across almost all cell types and character...

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Literature Corpus work: a37f2c8d-c962-528e-8866-923d8b64e1b6
DOI: 10.1101/2025.03.23.644697

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