Article

Learning the cellular origins of cancer using single-cell chromatin landscapes

2025-04-06

Abstract excerpt

<h4>ABSTRACT</h4> Deciphering the cell of origin (COO) of different cancers is critical for understanding tumor development and improving diagnostic and therapeutic strategies in oncology. Previous studies demonstrated that the COO chromatin accessibility landscape shapes the genomic distribution of cancer somatic mutations. We leveraged machine learning, 559 single-cell chromatin accessibility cellular profiles,...

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Literature Corpus work: f4038d50-1779-50c2-b9e6-63502c94e647
DOI: 10.1101/2025.04.06.646131

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