Article

Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof-of-Concept Synthesis of Landscape-Level Regulation

2026-02-06

Abstract excerpt

<h4> ABSTRACT </h4> <h4>Background</h4> Phase-separated oncogenic condensates act as biophysical sanctuaries, stabilizing transcriptional and survival programs to drive cancer progression. While individual proteins within these assemblies are well-documented, a universal regulator capable of orchestrating the integrated biophysical axes governing cellular phase behavior has remained elusive. We propose a paradi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2cdc8907-b50d-5d2a-b950-7e281c781742
DOI: 10.64898/2026.02.03.703596

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof-of-Concept Synthesis of Landscape-Level RegulationDOI 10.64898/2026.02.03.703596Read

Phase-Separated Biomolecular Condensation in Cancer: New Horizons and Next Frontiers.Semantic proximity Read

Phase-separating fusion proteins drive cancer by dysregulating transcription through ectopic condensatesSemantic proximity Read

An Integrative Multi-Omics Analysis Based On Liquid-liquid Phase Separation Delineates Distinct Subtypes of Lower-Grade Glioma and Identifies a Prognostic SignatureSemantic proximity Read

Phase separation of Myc differentially modulates the transcriptomeSemantic proximity Read

An integrative multi-omics analysis based on liquid–liquid phase separation delineates distinct subtypes of lower-grade glioma and identifies a prognostic signatureSemantic proximity Read

A single-nucleus multimodal framework reveals epigenomic priming of chemoresistant states in ovarian cancerSemantic proximity Read

Aberrant phase separation and cancer.Semantic proximity Read

Liquid‒liquid phase separation: roles and implications in future cancer treatment.Semantic proximity Read

Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing’s sarcomaSemantic proximity Read

Protein phase separation and its role in tumorigenesis.Semantic proximity Read

YAP1-2α heterodimerization with TAZ promotes cancer aggressiveness through BRD4-dependent liquid-liquid phase separation at super-enhancersSemantic proximity Read

Integrative Multi-Omics and Single-Cell Analyses Reveal that Polyamine Metabolic Reprogramming Shapes an Immunosuppressive Microenvironment and Identifies ZWINT as a Prognostic Biomarker and Therapeutic Target in Lung AdenocarcinomaSemantic proximity Read