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Article

Intrinsic transcriptional heterogeneity in neuroblastoma guides mechanistic and therapeutic insights

1 May 2022

Abstract excerpt

Cell state is controlled by master transcription factors (mTFs) that determine the cellular gene expression program. Cancer cells acquire dysregulated gene expression programs by mutational and non-mutational processes. Intratumoral heterogeneity can result from cells displaying distinct mTF-regulated cell states, which co-exist within the tumor. One archetypal tumor associated with transcriptionally regulated...

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PMID: 35584622
DOI: 10.1016/j.xcrm.2022.100632

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