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Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing’s sarcoma

2 Aug 2024

Abstract excerpt

Liquid-liquid phase separation (LLPS) facilitates the formation of membraneless organelles within cells, with implications in various biological processes and disease states. AT-rich interactive domain-containing protein 1A (ARID1A) is a chromatin remodeling factor frequently associated with cancer mutations, yet its functional mechanism remains largely unknown. Here, we find that ARID1A harbors a prion-like...

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PMID: 39095374
DOI: 10.1038/s41467-024-51050-0

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