Article

YAP1-2α heterodimerization with TAZ promotes cancer aggressiveness through BRD4-dependent liquid-liquid phase separation at super-enhancers

2025-01-29

Abstract excerpt

<h4>SUMMARY</h4> The pro-oncogenic transcriptional coactivator YAP1 comprises multiple splice isoforms, including YAP1-2α, which retains an intact leucine zipper by skipping exon 6. Here, we show that YAP1-2α has a markedly greater capacity to form nuclear condensates via liquid-liquid phase separation (LLPS) than other YAP1 isoforms. Mechanistically, the YAP1-2α/TEAD complex interacts with the TAZ/TEAD complex t...

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Literature Corpus work: b846ceb0-4358-5a13-a103-925b9db206c1
DOI: 10.1101/2025.01.28.635202

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YAP1-2α heterodimerization with TAZ promotes cancer aggressiveness through BRD4-dependent liquid-liquid phase separation at super-enhancersDOI 10.1101/2025.01.28.635202Read

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