Article

Divergent somatic mutation patterns among human cerebellar neuron types

2025-09-30

Abstract excerpt

Neurons in the human brain accumulate somatic mutations with age. However, it is largely unknown how somatic mutation rates and patterns vary among the brain’s diverse types of neurons. Characterizing this variability is critical for elucidating the role of genome integrity in human brain function and disease. Moreover, the significant physiological differences among the brain’s cell types provides an opportunity...

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Literature Corpus work: bbceb005-a404-5d6e-a092-b75969e4582a
DOI: 10.1101/2025.09.29.679392

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