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The Complete Genome Sequences, Unique Mutational Spectra, and Developmental Potency of Adult Neurons Revealed by Cloning.

Neuron - 16 Mar 2016

Hazen Jennifer L, Faust Gregory G, Rodriguez Alberto R, Ferguson William C, Shumilina Svetlana, Clark Royden A, Boland Michael J, Martin Greg, Chubukov Pavel, Tsunemoto Rachel K, Torkamani Ali, Kupriyanov Sergey, Hall Ira M, Baldwin Kristin K

Abstract excerpt

Somatic mutation in neurons is linked to neurologic disease and implicated in cell-type diversification. However, the origin, extent, and patterns of genomic mutation in neurons remain unknown. We established a nuclear transfer method to clonally amplify the genomes of neurons from adult mice for whole-genome sequencing. Comprehensive mutation detection and independent validation revealed that individual neurons...

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Identifiers

PMID: 26948891
DOI: 10.1016/j.neuron.2016.02.004
PMCID: PMC4795965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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