Article

Contrasting patterns of somatic mutations in neurons and glia reveal differential predisposition to disease in the aging human brain

2023-01-14

Abstract excerpt

<h4>SUMMARY</h4> Characterizing the mechanisms of somatic mutations in the brain is important for understanding aging and disease, but little is known about the mutational patterns of different cell types. We performed whole-genome sequencing of 71 oligodendrocytes and 51 neurons from neurotypical individuals (0.4 to 104 years old) and identified >67,000 somatic single nucleotide variants (sSNVs) and small insert...

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Literature Corpus work: 444830c3-6552-5903-b1fd-e6ce578b2b88
DOI: 10.1101/2023.01.14.523958

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