Article

Somatic mutation in human cerebellum illustrates neuron type-specific patterns of age-related mutation

2026-03-02

Abstract excerpt

Human neurodegenerative disorders are characterized by exquisite specificity for neuronal types, but the basis of this is unknown. Here, we show that cerebellar granule neurons (GN)—the most abundant neuronal type in the human brain—accumulate somatic mutations in patterns highly distinct from cerebral cortical neurons, and more closely resembling oligodendroglia and other dividing cells. We find shared mutational...

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Literature Corpus work: f3a6ca25-9b8c-514f-81d1-0ae112b57d5e
DOI: 10.64898/2026.02.27.708647

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