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Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes.

Cell - 11 Apr 2024

Ganz Javier, Luquette Lovelace J, Bizzotto Sara, Miller Michael B, Zhou Zinan, Bohrson Craig L, Jin Hu, Tran Antuan V, Viswanadham Vinayak V, McDonough Gannon, Brown Katherine, Chahine Yasmine, Chhouk Brian, Galor Alon, Park Peter J, Walsh Christopher A

Abstract excerpt

Characterizing somatic mutations in the brain is important for disentangling the complex mechanisms of aging, yet little is known about mutational patterns in different brain cell types. Here, we performed whole-genome sequencing (WGS) of 86 single oligodendrocytes, 20 mixed glia, and 56 single neurons from neurotypical individuals spanning 0.4-104 years of age and identified >92,000 somatic single-nucleotide...

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Identifiers

PMID: 38503282
DOI: 10.1016/j.cell.2024.02.025
PMCID: PMC11062076

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