Article

Cell-type-specific patterns and consequences of somatic mutation in development and aging brain

2025-06-01

Abstract excerpt

Elucidating the role of somatic mutations in cancer, healthy tissues, and aging depends on methods that can accurately characterize somatic mosaicism across different cell types, as well as assay their impact on cellular function. Current technologies to study cell-type-specific somatic mutations within tissues are low-throughput. We developed Duplex-Multiome, incorporating duplex consensus sequencing to accuratel...

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Literature Corpus work: b3a91334-76e4-5a66-8099-f90305fae212
DOI: 10.1101/2025.05.30.656844

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