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A hypermorphic Nfkbid allele represents an Idd7 locus gene contributing to impaired thymic deletion of autoreactive diabetogenic CD8 + T-cells in NOD mice

2018-01-22

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In both NOD mice and humans, the development of type 1 diabetes (T1D) is dependent in part on autoreactive CD8 + T-cells recognizing pancreatic ß-cell peptides presented by often quite common MHC class I variants. Studies in NOD mice previously revealed the common H2-K d and/or H2-D b class I molecules expressed by this strain acquire an aberrant ability to mediate pathogenic CD8 + T-cell responses through int...

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Literature Corpus work: bb61ebbf-9290-5dac-b328-9ea95e770bd2
DOI: 10.1101/249094

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A hypermorphic Nfkbid allele represents an Idd7 locus gene contributing to impaired thymic deletion of autoreactive diabetogenic CD8 + T-cells in NOD miceDOI 10.1101/249094Read

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A hypermorphic <i>Nfkbid</i> allele represents an <i>Idd7</i> locus gene contributing to impaired thymic deletion of autoreactive diabetogenic CD8 <sup>+</sup> T-cells in NOD mice

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