Article
An update on the use of NOD mice to study autoimmune (Type 1) diabetes.
Expert review of clinical immunology - 1 Nov 2010
Chaparro Rodolfo José, Dilorenzo Teresa P
Abstract excerpt
The widely used nonobese diabetic (NOD) mouse model of autoimmune (Type 1) diabetes mellitus shares multiple characteristics with the human disease, and studies employing this model continue to yield clinically relevant and important information. Here, we review some of the recent key findings obtained from NOD mouse investigations that have both advanced our understanding of disease pathogenesis and suggested...
Topics
- Animals
- Autoantigens
- Diabetes Mellitus, Type 1
- Disease Models, Animal
- Drug Discovery
- Genetic Predisposition to Disease
- Humans
- Immunologic Techniques
- Mice
- Mice, Inbred NOD