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Article

Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice.

Immunogenetics - 1 Sept 2007

Chen Yi-Guang, Driver John P, Silveira Pablo A, Serreze David V

Abstract excerpt

Reduced numbers and function of invariant NKT (iNKT) cells partially contribute to type 1 diabetes (T1D) development in NOD mice. Previous linkage analysis identified a genetic locus on chromosome 2 controlling numbers of thymic iNKT cells. Interestingly, this locus resides within the Idd13 region that distinguishes NOD mice from the closely genetically related, but strongly T1D-resistant NOR strain. Thus, we...

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Share to Antigens, CD1
Share to Diabetes Mellitus, Type 1
Share to Killer Cells, Natural

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Congenic

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Source

Identifiers

PMID: 17619875
DOI: 10.1007/s00251-007-0236-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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