Article
Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2008
Serreze David V, Choisy-Rossi Caroline Morgane, Grier Alexandra E, Holl T Mathew, Chapman Harold D, Gahagan J Reed, Osborne Melissa A, Zhang Weidong, King Benjamin L, Brown Aaron, Roopenian Derry, Marron Michele P
Abstract excerpt
When expressed in NOD, but not C57BL/6 (B6) genetic background mice, the common class I variants encoded by the H2g7 MHC haplotype aberrantly lose the ability to mediate the thymic deletion of autoreactive CD8+ T cells contributing to type 1 diabetes (T1D). This indicated some subset of the T1D susceptibility (Idd) genes located outside the MHC of NOD mice interactively impair the negative selection of...
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