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Article

Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice.

Diabetes - 1 Dec 2008

Chen Yi-Guang, Scheuplein Felix, Osborne Melissa A, Tsaih Shirng-Wern, Chapman Harold D, Serreze David V

Abstract excerpt

OBJECTIVE: Although the H2(g7) major histocompatibility complex (MHC) provides the primary pathogenic component, the development of T-cell-mediated autoimmune type 1 diabetes in NOD mice also requires contributions from other susceptibility (Idd) genes. Despite sharing the H2(g7) MHC, the closely...

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Share to Antigen-Presenting Cells
Share to CD8 Antigens
Share to Major Histocompatibility Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to T-Lymphocyte Subsets

Share to T-Lymphocytes, Regulatory

Source

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Identifiers

PMID: 18776136
DOI: 10.2337/db08-0767
PMCID: PMC2584133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18776136-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice.PMID 18776136Read ↗

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