Article
A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2018
Presa Maximiliano, Racine Jeremy J, Dwyer Jennifer R, Lamont Deanna J, Ratiu Jeremy J, Sarsani Vishal Kumar, Chen Yi-Guang, Geurts Aron, Schmitz Ingo, Stearns Timothy, Allocco Jennifer, Chapman Harold D, Serreze David V
Abstract excerpt
In both NOD mice and humans, the development of type 1 diabetes (T1D) is dependent in part on autoreactive CD8+ T cells recognizing pancreatic β cell peptides presented by often quite common MHC class I variants. Studies in NOD mice previously revealed that the common H2-Kd and/or H2-Db class I molecules expressed by this strain aberrantly lose the ability to mediate the thymic deletion of pathogenic CD8+ T cell...
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