Article

The human transcription factor occupancy landscape viewed using high-resolution in situ base-conversion strand-specific single-molecule chromatin accessibility mapping

2025-06-29

Abstract excerpt

Chromatin accessibility profiling is a key tool for mapping the location of cis -regulatory elements (cREs) in the genome and tracking chromatin state dynamics during development, in response to various external and internal stimuli, and in disease contexts. Single-molecule footprinting (SMF) methods that rely on the labeling of individual accessible DNA bases have emerged in recent years as a powerful chromatin...

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Literature Corpus work: 76518a78-0ec3-571b-afa0-8a9334d13fe0
DOI: 10.1101/2025.06.27.662080

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