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Article

Massively parallel synthetic promoter assays reveal the in vivo effects of binding site variants.

Genome research - 1 Nov 2013

Mogno Ilaria, Kwasnieski Jamie C, Cohen Barak A

Abstract excerpt

Gene promoters typically contain multiple transcription factor binding sites (TFBSs), which may vary in affinity for their cognate transcription factors (TFs). One major challenge in studying cis-regulation is to understand how TFBS variants affect gene expression. We studied the in vivo effects of TFBS variants on cis-regulation using synthetic promoters coupled with a thermodynamic model of TF binding. We...

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Identifiers

PMID: 23921661
DOI: 10.1101/gr.157891.113
PMCID: PMC3814890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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